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Dickkopf homolog 3 (DKK3): A candidate for detection and treatment of cancers?
Hamzehzadeh L, Caraglia M, Atkin SL, Sahebkar A. Hamzehzadeh L, et al. J Cell Physiol. 2018 Jun;233(6):4595-4605. doi: 10.1002/jcp.26313. Epub 2018 Jan 15. J Cell Physiol. 2018. PMID: 29206297 Review.
Wnt signaling is an evolutionary highly conserved pathway that is modulated by several inhibitors and activators, and plays a key role in numerous physiological processes. One of the extracellular Wnt inhibitors is the DKK (Dickkopf Homolog) family which has four members ( …
Wnt signaling is an evolutionary highly conserved pathway that is modulated by several inhibitors and activators, and plays a key role in nu …
Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling.
Wang X, Karamariti E, Simpson R, Wang W, Xu Q. Wang X, et al. J Biol Chem. 2015 Aug 7;290(32):19844-52. doi: 10.1074/jbc.M115.641415. Epub 2015 Jun 23. J Biol Chem. 2015. PMID: 26105053 Free PMC article.
Embryonic stem (ES) cells that have the remarkable capability to differentiate into vascular SMCs in response to specific stimuli provide a useful model for studying SMC differentiation. Previous studies suggested that dickkopf homolog 3 (DKK3) has a role in …
Embryonic stem (ES) cells that have the remarkable capability to differentiate into vascular SMCs in response to specific stimuli provide a …
Dickkopf Homolog 3 (DKK3) Acts as a Potential Tumor Suppressor in Gallbladder Cancer.
Gondkar K, Patel K, Patil Okaly GV, Nair B, Pandey A, Gowda H, Kumar P. Gondkar K, et al. Front Oncol. 2019 Oct 29;9:1121. doi: 10.3389/fonc.2019.01121. eCollection 2019. Front Oncol. 2019. PMID: 31737564 Free PMC article.
Loss of DKK3 gene is associated with a possible tumor suppressor role in human cancers. The role and regulation of DKK3 in GBC have not been studied. ...
Loss of DKK3 gene is associated with a possible tumor suppressor role in human cancers. The role and regulation of DKK3 in GBC have n …
The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation.
Untergasser G, Steurer M, Zimmermann M, Hermann M, Kern J, Amberger A, Gastl G, Gunsilius E. Untergasser G, et al. Int J Cancer. 2008 Apr 1;122(7):1539-47. doi: 10.1002/ijc.23255. Int J Cancer. 2008. PMID: 18033687 Free article.
Our study analyzed various solid tumor types for the expression of Dkk-3, a cystein-rich, N-glycosylated secreted member of the Dickkopf protein family that has been proposed as a tumor suppressor gene. ...
Our study analyzed various solid tumor types for the expression of Dkk-3, a cystein-rich, N-glycosylated secreted member of the Dickkopf …
Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/beta-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis.
Das DS, Wadhwa N, Kunj N, Sarda K, Pradhan BS, Majumdar SS. Das DS, et al. PLoS One. 2013 May 7;8(5):e63603. doi: 10.1371/journal.pone.0063603. Print 2013. PLoS One. 2013. PMID: 23667645 Free PMC article.
Sc are the target of follicle stimulating hormone (FSH) and testosterone (T) which are known to regulate spermatogenesis. FSH and T levels in human and sub-human male primates remain high during infancy (4-6 months post birth), similar to those during puberty. ...Di …
Sc are the target of follicle stimulating hormone (FSH) and testosterone (T) which are known to regulate spermatogenesis. FSH and T levels i …
A Review of Specific Biomarkers of Chronic Renal Injury and Their Potential Application in Nonclinical Safety Assessment Studies.
Obert LA, Elmore SA, Ennulat D, Frazier KS. Obert LA, et al. Toxicol Pathol. 2021 Jul;49(5):996-1023. doi: 10.1177/0192623320985045. Epub 2021 Feb 12. Toxicol Pathol. 2021. PMID: 33576319 Free PMC article. Review.
A host of novel renal biomarkers have been developed over the past few decades which have enhanced monitoring of renal disease and drug-induced kidney injury in both preclinical studies and in humans. Since chronic kidney disease (CKD) and acute kidney injury (AKI) share s …
A host of novel renal biomarkers have been developed over the past few decades which have enhanced monitoring of renal disease and drug-indu …
Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer.
Westin SN, Fellman B, Sun CC, Broaddus RR, Woodall ML, Pal N, Urbauer DL, Ramondetta LM, Schmeler KM, Soliman PT, Fleming ND, Burzawa JK, Nick AM, Milbourne AM, Yuan Y, Lu KH, Bodurka DC, Coleman RL, Yates MS. Westin SN, et al. Am J Obstet Gynecol. 2021 Feb;224(2):191.e1-191.e15. doi: 10.1016/j.ajog.2020.08.032. Epub 2020 Aug 15. Am J Obstet Gynecol. 2021. PMID: 32805208 Free PMC article. Clinical Trial.
Nonresponders had higher baseline proliferation (Ki67) and lower dickkopf homolog 3 gene expression than responders (P=.023 and P=.030). ...
Nonresponders had higher baseline proliferation (Ki67) and lower dickkopf homolog 3 gene expression than responders (P= …
Advanced molecular profiling in vivo detects novel function of dickkopf-3 in the regulation of bone formation.
Aslan H, Ravid-Amir O, Clancy BM, Rezvankhah S, Pittman D, Pelled G, Turgeman G, Zilberman Y, Gazit Z, Hoffmann A, Gross G, Domany E, Gazit D. Aslan H, et al. J Bone Miner Res. 2006 Dec;21(12):1935-45. doi: 10.1359/jbmr.060819. J Bone Miner Res. 2006. PMID: 17002559 Free article.
A bioinformatics-based analysis of endochondral bone formation model detected several genes upregulated in this process. Among these genes the dickkopf homolog 3 (Dkk3) was upregulated and further studies showed that its expression affects in vitro and in viv …
A bioinformatics-based analysis of endochondral bone formation model detected several genes upregulated in this process. Among these genes t …
Dkk-3 is elevated in CSF and plasma of Alzheimer's disease patients.
Zenzmaier C, Marksteiner J, Kiefer A, Berger P, Humpel C. Zenzmaier C, et al. J Neurochem. 2009 Jul;110(2):653-61. doi: 10.1111/j.1471-4159.2009.06158.x. Epub 2009 May 11. J Neurochem. 2009. PMID: 19457090 Free PMC article.
The present study investigated whether the glycoprotein and putative tumor suppressor Dickkopf homolog 3 (Dkk-3) is secreted into CSF and evaluated its applicability as a diagnostic marker for AD. ...
The present study investigated whether the glycoprotein and putative tumor suppressor Dickkopf homolog 3 (Dkk-3) is sec …
Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer.
Yu J, Tao Q, Cheng YY, Lee KY, Ng SS, Cheung KF, Tian L, Rha SY, Neumann U, Röcken C, Ebert MP, Chan FK, Sung JJ. Yu J, et al. Cancer. 2009 Jan 1;115(1):49-60. doi: 10.1002/cncr.23989. Cancer. 2009. PMID: 19051296 Free article.
In this study, the authors investigated the promoter methylation of the dickkopf homolog 3 gene Dkk-3 in these cancers and its prognostic significance in gastric cancer. ...
In this study, the authors investigated the promoter methylation of the dickkopf homolog 3 gene Dkk-3 in these cancers …
13 results